Research, Studies & Publications

Prof Thomas Seyfried et al., & the Ketogenic Diet

Please see a range of studies below. Some of these are authored or co-authored by Prof Thomas Seyfried, whose work follows upon the work of Nobel Prize winner Dr Otto Warburg. 

In his book 'CANCER AS A METABOLIC DISEASE', Prof Seyfried presents an origin of cancer based on the theories of Dr Warburg, wherein cancer is viewed as a disease of cellular metabolic dysfunction due to damaged mitochondria. He elaborates on a non-toxic mode of treatment, the ketogenic diet, which capitalizes on the inability of the damaged cancer cell mitochondria to metabolize ketones, thus starving them while maintaining healthy cells.

Prof Seyfried is Professor of Biology at Boston College. He is a senior editor of the American Society of Neurochemistry's journal ASN Neuro and is on the editorial boards of Journal of Lipid Research, Neurochemical Research and Nutrition & Metabolism.

A range of studies on the ketogenic diets and cancer as a metabolic disease are included below, including very important work being undertaken in New Zealand on glioblastoma by Dr Matthew Phillips:

Frontiers | Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study 

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report - Nutrition & Metabolism 

Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma - BMC Medicine 

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma 

A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle - Journal of Experimental & Clinical Cancer Research 

4-Year Long Progression-Free and Symptom-Free Survival of a Patient with Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used as a Stand-Alone Treatment After Failed Standard Oncotherapy 

Metabolic therapy in glioblastoma: Ancestral strategies | Dr Matthew Phillips | FOM23 

Frontiers | Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up 

Ketogenic Diet in the Treatment of Gliomas and Glioblastomas - PMC 

Frontiers | Metabolic management of microenvironment acidity in glioblastoma 

Effects of ketogenic diet on oxidative stress and cancer: A literature review 

Glutamine metabolism in cancer therapy 

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer 

Insulin-Lowering Diets in Metastatic Cancer 

Ketogenic diets: from cancer to mitochondrial diseases and beyond 

Interview with Thomas N. Seyfried on Cancer as a metabolic disease: On the origin, management, and prevention of cancer 

Prof Seyfried’s website is here: https://tomseyfried.com/